Location: Soncy Rd and Amarillo Blvd, Amarillo Immediately after I-40, we’ll approach I-40 Business/Route 66. Location: Soncy Rd and Amarillo Blvd, Amarillo Turn left for I-40 Business west and right for I-40 Business east.  N to TX-RM1061, S to TX-FM2186/TX-FM2590  W to I-40, E to TX-279 Spur  W to I-40 Bus, E to I-27/US-60/US-87/US-287